Meanwhile, Sheffield United are forced into two changes from their 1-0 win over Norwich City last time out. Having sustained contact injuries in training, Jack O’Connell and John Fleck miss out for the first time this season. Jack Robinson comes into the three-man defence and January signing Sander Berge comes into midfield.
Villa were beaten 4-0 by Leicester City in the last Premier League game back in March. Dean Smith makes six changes from that game with Orjan Nyland given the nod in goal ahead of on-loan Pepe Reina, while Keinan Davis leads a three-man attack alongside Anwar El Ghazi and skipper Jack Grealish. The hosts also welcome back John McGinn, who is available having been ruled out since December with a fractured ankle.
SUBS: Simon Moore, Phil Jagielka, Jack Rodwell, David McGoldrick, Kieron Freeman, Luke Freeman, Ben Osborn, Lys Mousset, Leon Clarke.
SHEFFIELD UNITED (3-5-2): Dean Henderson; Chris Basham, John Egan, Jack Robinson; George Baldock, John Lundstram, Oliver Norwood, Sander Berge, Enda Stevens; Oli McBurnie, Billy Sharp (captain).
SUBS: Pepe Reina, Neil Taylor, Marvelous Nakamba, Trezeguet, Borja Baston, Mbwana Samatta, Jota, Ahmed Elmohamady, Indiana Vassilev.
ASTON VILLA (4-3-3): Orjan Nyland; Ezri Konsa, Kourtney Hause, Tyrone Mings, Matt Targett; Conor Hourihane, Douglas Luiz, John McGinn; Anwar El Ghazi, Keinan Davis, Jack Grealish (captain).
The Premier League relaunches with a game featuring two sides desperate for three points in their respective pursuits. Victory would lift Villa out of the relegation zone, while three points would lift United up to fifth place in the table.
Hello everyone and welcome to the return of the Premier League! Exactly 100 days since the last game, the English top flight resumes at Villa Park, where Aston Villa take on Sheffield United.